Fidelity: Episode 7

Fidelity:

This episode begins with marital difficulties, a theme that runs roughshod over the Holmes canon (Take, for example, Watson's treatment of his own wife, forever abandoning her to go gallivanting off with Holmes. Also, a large amount of cases include unhappy marriages, relationships, and engagements.)

House later states, that he, "didn't realize it was possible for a woman to be unusually irritable."
Leading Cameron to tell him that he's a, "misanthrope, not a misogynist."
But he's damn well close enough, and Holmes certainly is.

He goes on to call Wilson in for a consult on a clinic patient with large, recently plastic-surgery created breasts, claiming that Wilson is, "somewhat of an expert in these matters."
Which somewhat reminded me of Holmes saying (in SECO) that the "fair sex is [Watson's] department."

Wilson: You can be a real jerk sometimes, you know that?
H: And you're the good guy.
W: At least I try.

This seems to me to be a neat sum up of not only House and Wilson but Holmes and Watson. Wilson and Watson try to be the good guy and are accepted by others to be the good guy, but are willing to sacrifice morals for the sakes of Houses' and Holmes' schemes. House and Holmes, however, have realized that if they simply don't try to be good, they can say and do whatever they want.